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Once you reach sufficiently high level, you can unlock a Rune Combo by upgrading your runes a specific number of times in the right order.  Each unlocked Rune Combo permanently adds +1000% to your DPS. None of the combos use Kha, the first rune.  They use all the other five runes.  To unlock a Rune Combo, you must have sufficient gold to perform multiple upgrades, then follow one of the formulas below by tapping on each rune to upgrade it the specified number of times.

Combos by Rune OrderEdit

Eyr is b, Cie is c, Gish is d, Prea is e, & Ary is f.

1b-1c-2d-3e-5f

5b-4c-3d-2e-1f

1b-2c-3d-2e-1f

2b-2c-2d-2e-2f

5f-4e-3d-2c-2b

3c-4d-5e-4f-3b

5f-5e-5d-5c-5b

3b-2d-1f-2c-3e

2d-3c-4e-3b-2f

5e-1b-3f-2c-4d

Combos by Rune NameEdit

1 eyr - 1 cie - 2 gish - 3 prea - 5 ary

5 eyr - 4 cie - 3 gish - 2 prea - 1 ary

1 eyr - 2 cie - 3 gish - 2 prea - 1 ary

2 eyr - 2 cie - 2 gish - 2 prea - 2 ary

5 ary - 4 prea - 3 gish - 2 cie - 2 eyr

3 cie - 4 gish - 5 prea- 4 ary - 3 eyr

5 ary - 5 prea - 5 gish - 5 cie - 5 eyr

3 eyr - 2 gish - 1 ary - 2 cie - 3 prea

2 gish - 3 cie - 4 prea - 3 eyr - 2 ary

5 prea - 1 eyr - 3 ary - 2 cie - 4 gish